An important step in the research was leveraging artificial intelligence to find novel metabolite and proteomic associations to biological aging. During this process, Harvard researchers asked which metabolites, clinical values, and proteins were most predictive of longevity. They found a total of 38 individual factors which were predictive of time until death. Furthermore, they were able to find several nutrition-related biomarkers which we used to design the best in class supplement to improve epigenetic aging. Together, we believe that InfiniAge™ is the strongest combination of ingredients to reverse the most predictive, biological age biomarkers to date.
Based on that information, InfiniAge™ was born. It contains a precise blend of 7 key ingredients, including Calcium Alpha-Ketoglutarate, Uridine Monophosphate, Ergothionine, N-Acetyl L-Cysteine, Lutein (Carotene-2,2,-diol) Aronia Melanocarpa Extract, and Zinc. Many of these ingredients have vast publications which describe a multitude of benefits with regard to the aging process. We have also included what could be considered novel ingredients, relative to longevity, into this formulation as well. Each of these has been specifically identified in the OMICm Age algorithm which can beneficially impact OMICm Age factors.
For instance, in the development of OMICm Age, we took into effect that individuals who had higher plasma concentrations of Uridine and Lutein were generally associated to have a better OMICm Age; and as a result, have longer lives with less morbidity. We also included ingredients to change other OMICm Age measured variables, such as zinc and Aronia Melanocarpa Extract. Zinc and Aronia Melanocarpa Extract help to support healthy levels of PON1.
Serum paraoxonase and arylesterase 1 (PON1) is an enzyme encoded by the PON1 gene. Serum PON1 is secreted mainly by the liver, although local synthesis occurs in several tissues, PON1 protein is found in almost all tissues. PON1 is also a major beneficial component of HDL Cholesterol (good cholesterol). The PON1 gene is activated by PPAR-γ, which promotes synthesis and release of paraoxonase 1 enzyme from the liver. In the OMICm Age cohort, researchers found that higher levels of PON1 activity were associated with better aging.
